Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

BMS-561392 Formic acid

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Cat# NB-64-19365-25mg

Size : 25mg

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BMS-561392 Formic acid

(Synonyms: BMS-561392 Formic acid(611227-74-8 Free base)) Copy Product Info

Synonyms: BMS-561392 Formic acid(611227-74-8 Free base)

Catalog No. T30531L Copy Product Info

Purity: 97.00%

BMS-561392 Formic acid (BMS-561392 formate) is a small molecule inhibitor, the formate salt form of BMS-561392. As a selective TACE inhibitor and ADAM17 blocker, this compound reduces TNFα levels and is primarily used for research on inflammation-related diseases such as inflammatory bowel disease.

Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:97.00%

ee:100%

Appearance:Solid

Color:White

Product Introduction

Bioactivity

Description	BMS-561392 Formic acid (BMS-561392 formate) is a small molecule inhibitor, the formate salt form of BMS-561392. As a selective TACE inhibitor and ADAM17 blocker, this compound reduces TNFα levels and is primarily used for research on inflammation-related diseases such as inflammatory bowel disease.
Synonyms	BMS-561392 Formic acid(611227-74-8 Free base)

Chemical Properties

Molecular Weight	522.59
Formula	C₂₈H₃₄N₄O₆
Smiles	N[C@]1(C2=CC=C(C=C2)OCC3=CC(C)=NC4=C3C=CC=C4)C(N(CC1)[C@H](CC(C)C)C(NO)=O)=O.O=C(14)O
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (478.39 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9135 mL	9.5677 mL	19.1355 mL	95.6773 mL
5 mM	0.3827 mL	1.9135 mL	3.8271 mL	19.1355 mL
10 mM	0.1914 mL	0.9568 mL	1.9135 mL	9.5677 mL
20 mM	0.0957 mL	0.4784 mL	0.9568 mL	4.7839 mL
50 mM	0.0383 mL	0.1914 mL	0.3827 mL	1.9135 mL
100 mM	0.0191 mL	0.0957 mL	0.1914 mL	0.9568 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

BMS-561392 Formic acidADAM17/TACE

Related Tags: BMS-561392 Formic acid chemical structure | BMS-561392 Formic acid formula | BMS-561392 Formic acid molecular weight