Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

Aristolochic acid C [4849-90-5]

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Cat# NB-64-61837-1mg

Size : 1mg

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Aristolochic acid C

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Synonyms:

Catalog No. TN1064 Copy Product Info

Purity: 99.8%

Aristolochic acid C, a derivative of Aristolochic acid, acts as a phospholipase A2 inhibitor.

Cas No. 4849-90-5

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.8%

Appearance:Solid

Color:Orange

Product Introduction

Aristolochic acid C AI Summary

Aristolochic acid C exhibits a bioactivity of inhibiting CDK2 with an IC50 value of 30,000 nM. Additionally, it shows anti-inflammatory activity in human neutrophils by inhibiting fMLP/CB-induced superoxide anion generation and elastase release after 5 minutes, with an IC50 value greater than 10.0 µg/mL, indicating moderate to weak inhibitory activity at this concentration..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Aristolochic acid C, a derivative of Aristolochic acid, acts as a phospholipase A2 inhibitor.

Chemical Properties

Molecular Weight	327.25
Formula	C₁₆H₉NO₇
Cas No.	4849-90-5
Smiles	OC(=O)c1cc2OCOc2c2c3cc(O)ccc3cc([N+]([O-])=O)c12
Relative Density.	1.707 g/cm3

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (381.97 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (12.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0558 mL	15.2788 mL	30.5577 mL	152.7884 mL
5 mM	0.6112 mL	3.0558 mL	6.1115 mL	30.5577 mL
10 mM	0.3056 mL	1.5279 mL	3.0558 mL	15.2788 mL
20 mM	0.1528 mL	0.7639 mL	1.5279 mL	7.6394 mL
50 mM	0.0611 mL	0.3056 mL	0.6112 mL	3.0558 mL
100 mM	0.0306 mL	0.1528 mL	0.3056 mL	1.5279 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

PhospholipaseInhibitorinhibitAristolochic acid C

Related Tags: Aristolochic acid C chemical structure | Aristolochic acid C formula | Aristolochic acid C molecular weight