Reagenti e strumenti per immunologia, biologia cellulare e biologia molecolare

alpha-D-glucose [492-62-6]

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Cat# NB-64-29112-50mg

Size : 50mg

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alpha-D-glucose

(Synonyms: α-D-Glucose, α-Dextrose, alpha-Glucose) Copy Product Info

Synonyms: α-D-Glucose, α-Dextrose, alpha-Glucose

Catalog No. T4884 Copy Product Info

Purity: 99.87%

alpha-D-glucose (α-Dextrose) is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.

Cas No. 492-62-6

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.87%

Appearance:Solid

Color:White

Product Introduction

alpha-D-glucose AI Summary

alpha-D-glucose shows a broad spectrum of bioactivities. It has very low partition coefficients, with logP values below -3, indicating a preference for partitioning into water over dodecane. In terms of its biochemical interactions, alpha-D-glucose demonstrates competitive inhibition of rabbit muscle glycogen phosphorylase b with a Ki value of 1,700,000.0 nM and has additional inhibitory effects on liver glycogen phosphorylase a, with Ki values ranging up to 4,900,000.0 nM. The compound also promotes [1-3H]-2-deoxy-D-glucose uptake in 3T3 L1 adipocytes, with observed activity of 34.0 Bq. In antiviral assays, alpha-D-glucose inhibits SARS-CoV-2 induced cytotoxicity of Caco-2 cells at a 10 uM concentration after 48 hours with an inhibition rate of 32.8%, though other assays showed a lower inhibition rate of 12.57% on SARS-CoV-2 3CL-Pro protease activity at a 20 µM concentration. Additionally, it interacts with calf thymus DNA, displacing EtBr with a C50 of 390.0 uM, and significantly increases the melting temperature of the DNA-ligand complex by 10.3°C. Furthermore, it shows inhibitory activities against human HDAC6, with inhibition percentages of -23.98% and -14.18% using different peptide substrates. These diverse bioactivities suggest potential applications in enzyme inhibition, antiviral therapy, and modulation of DNA-protein interactions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	alpha-D-glucose (α-Dextrose) is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Synonyms	α-D-Glucose, α-Dextrose, alpha-Glucose

Chemical Properties

Molecular Weight	180.16
Formula	C₆H₁₂O₆
Cas No.	492-62-6
Smiles	C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)O1
Relative Density.	1.544g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (249.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5506 mL	27.7531 mL	55.5062 mL	277.5311 mL
5 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
10 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
20 mM	0.2775 mL	1.3877 mL	2.7753 mL	13.8766 mL
50 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL
100 mM	0.0555 mL	0.2775 mL	0.5551 mL	2.7753 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

α-GlucoseInhibitorinhibitEndogenousMetaboliteEndogenous Metabolitealpha-D-glucosealphaDglucosealpha-Dextrosealpha D glucosea-Glucosea-D-Glucosea-Dextrose

Related Tags: alpha-D-glucose chemical structure | alpha-D-glucose formula | alpha-D-glucose molecular weight