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Prazosin [19216-56-9]

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Référence NB-64-11665-1mL

Conditionnement : 1mLx10mM(inDMSO)

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Prazosin

(Synonyms: Prazosine, Prazocin, Furazosin) Copy Product Info

Synonyms: Prazosine, Prazocin, Furazosin

Catalog No. T22406 Copy Product Info

Purity: 99.89%

Prazosin (Prazosine), an α1-blocker, acts as an inverse agonist at alpha-1 adrenergic receptors and is used to treat hypertension.

Cas No. 19216-56-9

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.89%

Appearance:Solid

Color:White

Product Information

Prazosin AI Summary

Prazosin exhibits strong alpha-1 adrenergic receptor antagonism with a very high binding affinity, demonstrated by Ki values ranging from 0.19 nM to 0.32 nM across different assays. It shows a significantly lower affinity for the alpha-2 adrenergic receptor, with Ki values up to 4830.0 nM. This compound is highly selective for alpha-1 receptors over alpha-2 receptors, indicated by a selectivity ratio of around 1258.9. Prazosin effectively reduces blood pressure in spontaneously hypertensive rats, showing dose-dependent antihypertensive activity with a maximum reduction of 45.0 mmHg at an oral dose of 30 mg/kg. It also exhibits significant vasorelaxant activity, blocking norepinephrine-induced contractions in rat and rabbit arterial tissues. Furthermore, Prazosin demonstrates robust antagonist activity in various adrenergic subtypes, notably alpha-1A, alpha-1B, and alpha-1D adrenergic receptors. Along with the cardiovascular functions, it also shows potential in modulating neurotransmitter responses, given its efficacy in displacing radioligands like [3H]prazosin from rat cerebral cortex membranes and displaying antagonist activity at the dopamine D2 receptors. Prazosin's effective oral bioavailability and selective inhibition properties make it a promising candidate for addressing cardiovascular conditions such as hypertension..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Prazosin (Prazosine), an α1-blocker, acts as an inverse agonist at alpha-1 adrenergic receptors and is used to treat hypertension.
Synonyms	Prazosine, Prazocin, Furazosin

Chemical Properties

Molecular Weight	383.4
Formula	C₁₉H₂₁N₅O₄
Cas No.	19216-56-9
Smiles	NC=1C2=C(N=C(N1)N3CCN(C(=O)C4=CC=CO4)CC3)C=C(OC)C(OC)=C2
Relative Density.	1.352g/cm3

Storage & Solubility Information

Storage

Store under nitrogen, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (130.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6082 mL	13.0412 mL	26.0824 mL	130.4121 mL
5 mM	0.5216 mL	2.6082 mL	5.2165 mL	26.0824 mL
10 mM	0.2608 mL	1.3041 mL	2.6082 mL	13.0412 mL
20 mM	0.1304 mL	0.6521 mL	1.3041 mL	6.5206 mL
50 mM	0.0522 mL	0.2608 mL	0.5216 mL	2.6082 mL
100 mM	0.0261 mL	0.1304 mL	0.2608 mL	1.3041 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

α1-adrenergic receptorPrazosinInhibitorinhibitBeta ReceptorAdrenergicReceptorAdrenergic Receptor

Related Tags: Prazosin chemical structure | Prazosin formula | Prazosin molecular weight