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Cephalosporin C zinc salt [59143-60-1]

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Conditionnement : 25mg

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Cephalosporin C zinc salt

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Synonyms:

Catalog No. T7142 Copy Product Info

Purity: 99.14%

Cephalosporin C zinc salt was a potent inhibitor of SAMHD1 (IC50 : 1.1 ± 0.1 μM), and this inhibition was largely attributable to the presence of zinc.

Cas No. 59143-60-1

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.14%

Appearance:Solid

Color:White

Product Introduction

Cephalosporin C zinc salt AI Summary

Cephalosporin C zinc salt displays a diverse range of bioactivities. It exhibits high potency as a modulator of Lamin A splicing with an IC50 value of 4.0 nM. As an inhibitor, it targets several enzymes and interactions with varying degrees of effectiveness: Human Jumonji Domain Containing 2E (JMJD2E) at 28183.8 nM, Tyrosyl-DNA Phosphodiesterase (TDP1) at 25118.9 nM, and Bloom's syndrome helicase (BLM) also at 28183.8 nM. The compound inhibits the proliferation of Plasmodium falciparum lines W2 and GB4 with potencies of 10000.0 nM and 5011.9 nM, respectively. For Tau fibril formation, it shows potencies of 7079.5 nM measured by Thioflavin T binding and 7943.3 nM measured by fluorescence polarization. Additionally, Cephalosporin C zinc salt has an IC50 of 12589.3 nM as an inhibitor targeting the Menin-MLL interaction in MLL-related leukemias, and 19952.6 nM for inhibiting the binding or entry of the Marburg Virus into cells. It also inhibits MPP8 Chromodomain interactions with methylated histone tails and Polymerase Iota, both with potencies of 44668.4 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cephalosporin C zinc salt was a potent inhibitor of SAMHD1 (IC50 : 1.1 ± 0.1 μM), and this inhibition was largely attributable to the presence of zinc.
Targets & IC50	SAMHD1:1.1 μM

Chemical Properties

Molecular Weight	478.78
Formula	C₁₆H₁₉N₃O₈SZn
Cas No.	59143-60-1
Smiles	CC(OCC1=C(N2[C@@H]([C@@H](C2=O)NC(CCC[C@H](C([O-])=O)N)=O)SC1)C([O-])=O)=O.[Zn+2]
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4.5 mg/mL (9.4 mM), when pH is adjusted to 6 with HCl. Sonication is recommmended.

0.1 M HCl: 5 mg/mL (10.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO/0.1 M HCl

	1mg	5mg	10mg	50mg
1 mM	2.0886 mL	10.4432 mL	20.8864 mL	104.4321 mL
5 mM	0.4177 mL	2.0886 mL	4.1773 mL	20.8864 mL

0.1 M HCl

	1mg	5mg	10mg	50mg
10 mM	0.2089 mL	1.0443 mL	2.0886 mL	10.4432 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Keywords

SAMHD1OrthopoxvirusInhibitorinhibitCephalosporin C zinc saltCephalosporin C zincCephalosporin CBacterialAntibiotic

Related Tags: Cephalosporin C zinc salt chemical structure | Cephalosporin C zinc salt formula | Cephalosporin C zinc salt molecular weight