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PDGFR Tyrosine Kinase Inhibitor III [205254-94-0]

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Référence NB-64-30566-5mg

Conditionnement : 5mg

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PDGFR Tyrosine Kinase Inhibitor III

(Synonyms: PDGF Receptor Tyrosine Kinase Inhibitor III) Copy Product Info

Synonyms: PDGF Receptor Tyrosine Kinase Inhibitor III

Catalog No. T60108 Copy Product Info

Purity: 99.50%

PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that inhibits PDGFR, EGFR, FGFR, PKA, and PKC and can be used for research on amyotrophic lateral sclerosis [1].

Cas No. 205254-94-0

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.50%

Appearance:Solid

Color:White

Product Introduction

PDGFR Tyrosine Kinase Inhibitor III AI Summary

PDGFR Tyrosine Kinase Inhibitor III inhibits the phosphorylation of platelet-derived growth factor receptor beta (PDGFRβ) in intact cells with an IC50 value of 80.0 nM. It also inhibits PDGFRβ phosphorylation in CHO cells with an IC50 greater than 80.0 nM. Additionally, it targets other receptors and kinases, including platelet-derived growth factor receptor alpha (IC50 50.0 nM), mast/stem cell growth factor receptor (c-Kit kinase, IC50 50.0 nM), Flt3 kinase (IC50 230.0 nM), and PDGF-BB-induced proliferation of porcine aorta smooth muscle cells (IC50 250.0 nM). PDGFR Tyrosine Kinase Inhibitor III exhibits low activity against the epidermal growth factor receptor, fibroblast growth factor receptor kinase, Src protein tyrosine kinase, protein kinase A (PKA), and protein kinase C, with IC50 values greater than 30,000.0 nM. It also demonstrates varying potencies as an inhibitor in assays involving TGF-β, human tyrosyl-DNA phosphodiesterase 1 (TDP1) in the presence and absence of CPT, and stage-specific inhibitors of Vaccinia Orthopoxvirus, with IC50 values ranging from 10,000.0 nM to 12,589.3 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor that inhibits PDGFR, EGFR, FGFR, PKA, and PKC and can be used for research on amyotrophic lateral sclerosis [1].
Synonyms	PDGF Receptor Tyrosine Kinase Inhibitor III

Chemical Properties

Molecular Weight	485.53
Formula	C₂₇H₂₇N₅O₄
Cas No.	205254-94-0
Smiles	O(C)C1=CC=2C(=NC=NC2C=C1OC)N3CCN(C(NC4=CC=C(OC5=CC=CC=C5)C=C4)=O)CC3
Relative Density.	1.310 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (102.98 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0596 mL	10.2980 mL	20.5960 mL	102.9802 mL
5 mM	0.4119 mL	2.0596 mL	4.1192 mL	20.5960 mL
10 mM	0.2060 mL	1.0298 mL	2.0596 mL	10.2980 mL
20 mM	0.1030 mL	0.5149 mL	1.0298 mL	5.1490 mL
50 mM	0.0412 mL	0.2060 mL	0.4119 mL	2.0596 mL
100 mM	0.0206 mL	0.1030 mL	0.2060 mL	1.0298 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Keywords

PDGFR Tyrosine Kinase Inhibitor IIIPDGFR

Related Tags: PDGFR Tyrosine Kinase Inhibitor III chemical structure | PDGFR Tyrosine Kinase Inhibitor III formula | PDGFR Tyrosine Kinase Inhibitor III molecular weight