Conditionnement : 50mg
Téléphone : +1 850 650 7790
Synonyms:
| Description | EBOV-IN-5 (compound 14) serves as an antiviral agent targeting the Ebola virus (EBOV) by disrupting its entry mechanism into host cells. It specifically blocks the interaction between the EBOV glycoprotein EBOV-GPcl and the essential host receptor NPC1, which is crucial for the virus's fusion and entry into the cell. [7] [1] |
| In vitro | EBOV-IN-5 (compound 14) has a CC50 of 30 μM in HeLa cells and exhibits low cytotoxicity in Vero cells, with a CC50 of over 100 μM [1]. At a concentration of 50 μM, EBOV-IN-5 significantly disrupts the EBOV-GPcl/NPC1 interaction, with an IC50 of 4.69 μM against EBOV-GP-pseudotyped virus (pEBOV) [1]. Additionally, EBOV-IN-5 has an IC50 of 35.17 μM against the African swine fever virus (ASFV) [1]. |
| Molecular Weight | 408.9 |
| Formula | C18H21ClN4O3S |
| Cas No. | 68207-15-8 |
| Smiles | S(C1=C(N(=O)=O)C=CC(Cl)=C1)C2=C(NNC(CN(CC)CC)=O)C=CC=C2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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