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dGTP [2564-35-4]

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Référence NB-64-27571-10mg

Conditionnement : 10mg

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dGTP

(Synonyms: 2'-Deoxyguanosine-5'-triphosphate) Copy Product Info

Synonyms: 2'-Deoxyguanosine-5'-triphosphate

Catalog No. T40192 Copy Product Info

Purity: 99.64%

dGTP (2'-Deoxyguanosine-5'-triphosphate) is a guanosine nucleotide highly susceptible to oxidative damage, resulting in 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

Cas No. 2564-35-4

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.64%

Appearance:Solid

Color:White

Product Introduction

dGTP AI Summary

dGTP exhibits diverse bioactivities and stability profiles under various conditions. In human blood serum at 37 degrees Celsius, it has a short half-life of 0.3 hours, whereas in a phosphate buffer of pH 7.5, the half-life extends beyond 24 hours, indicating significant stability in this environment. Enzymatic kinetic studies show a Vmax of 13.1 pM U^-1 min^-1 and a Km of 62000.0 nM, yielding an efficiency ratio of 0.211. The compound demonstrates polymerizing activity with both exonuclease-deficient human recombinant DNA polymerase gamma E200A mutant and HSV1 DNA polymerase UL42 D368A mutant, with comparable Kd values of 800.0 nM, although the polymerization constant K/Kd ratio is higher for the HSV1 mutant. Additionally, dGTP acts on HIV1 reverse transcriptase, showing an activity rate of 7.5 /s and a binding affinity with a Kd of 4200.0 nM. Its inhibition efficiency for HIV1 reverse transcriptase is highlighted by a Vmax of 28.81 pmol/min and a Km of 540.0 nM, with a remarkably high efficiency ratio of Vmax/Km at 53.4 x 10^6/min. Furthermore, it maintains stability against dephosphorylation with a half-life of 1.0 hour. These multifaceted properties highlight the potential of dGTP in various biochemical and pharmacological applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	dGTP (2'-Deoxyguanosine-5'-triphosphate) is a guanosine nucleotide highly susceptible to oxidative damage, resulting in 8-O-GDP, 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
Synonyms	2'-Deoxyguanosine-5'-triphosphate

Chemical Properties

Molecular Weight	507.18
Formula	C₁₀H₁₆N₅O₁₃P₃
Cas No.	2564-35-4
Smiles	O=C1C2=C(N(C=N2)[C@@H]3O[C@H](COP(OP(OP(=O)(O)O)(=O)O)(=O)O)[C@@H](O)C3)NC(N)=N1

Storage & Solubility Information

Storage	Store at low temperature,Keep away from direct sunlight Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: Slightly soluble

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

synthesisRNASynthesisRNA SynthesisoxidativenucleotideNucleosideAntimetaboliteNucleoside Antimetabolite/AnalogNucleoside AntimetaboliteInhibitorinhibitguanosineDNASynthesisDNA/RNA SynthesisDNA SynthesisdGTPdeoxyribonucleicdamageAnalogacid

Related Tags: dGTP chemical structure | dGTP formula | dGTP molecular weight