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Cordycepin [73-03-0]

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Référence NB-64-18781-500mg

Conditionnement : 500mg

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Cordycepin

(Synonyms: 3'-Deoxyadenosine) Copy Product Info

Synonyms: 3'-Deoxyadenosine

Catalog No. T2993 Copy Product Info

Purity: 99.99%

Cordycepin (3'-Deoxyadenosine) is a purine nucleoside antimetabolite and antibiotic derived from the fungus [Cordyceps militaris], exhibiting potential antineoplastic activity.

Cas No. 73-03-0

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.99%

Color:White

Product Introduction

Cordycepin AI Summary

Cordycepin exhibits a diverse range of bioactivities across various pathogens and cellular systems. It demonstrates potent antiviral activity against Herpes Simplex Virus type-1 (HSV-1) in vero cells with an IC50 of 0.5 nM and other viruses including HSV-2, vaccinia virus, vesicular stomatitis virus, polio virus type 1, coxsackie B4 virus, parainfluenza virus type 3, reovirus type 1, sindbis virus, semliki forest virus, and HIV-1, with MIC values spanning from > 40.0 µg/mL to > 100.0 µg/mL. It inhibits Hepatitis C Virus (HCV) NS5B RNA synthesis at an IC50 of 22,000.0 nM and RNA replication at an EC50 of 46,000.0 nM, as well as cytopathic effects of HIV in MT-4 cells with an ED50 over 50.0 µM and cytotoxicity towards these cells at a CD50 of 45.0 µM. Additionally, Cordycepin shows a favorable selectivity for parasitic infections with an IC50 of 4.5 µg/mL for antimalarial activity, and displays trypanocidal activity with IC50 values ranging from 12.59 nM to 1122.02 nM depending on the assay. The compound is also active against Trypanosoma cruzi and Leishmania donovani. In terms of pharmacokinetics, oral administration of Cordycepin in C57BL/6 mice results in a Cmax of 10,100.0 nM, Tmax of 1.5 hours, AUC of 4824.0 ng.hr.mL^-1, and a half-life of 2.1 hours. It binds strongly to its target with a binding energy of -8.2 kCal mol^-1, shows affinity for the Adenosine A1 receptor with Ki values of 7120.0 nM without GTP and 15,200.0 nM with GTP (GTP shift of 2.1). Furthermore, it modulates PINK1 expression and inhibits multiple enzymes and cell line activities. Cordycepin also shows insufficient inhibition of SARS-CoV-2 cytotoxicity in specific assays and a weak inhibitory effect on the HDAC6 enzyme. Overall, these multifaceted activities underscore its potential therapeutic breadth, subject to further optimization for specificity and efficacy..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cordycepin (3'-Deoxyadenosine) is a purine nucleoside antimetabolite and antibiotic derived from the fungus [Cordyceps militaris], exhibiting potential antineoplastic activity.
Synonyms	3'-Deoxyadenosine

Chemical Properties

Molecular Weight	251.24
Formula	C₁₀H₁₃N₅O₃
Cas No.	73-03-0
Smiles	Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO)C[C@H]1O
Relative Density.	1.2938 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25.63 mg/mL (102.01 mM), Sonication is recommended.

H2O: 8.29 mg/mL (33 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9803 mL	19.9013 mL	39.8026 mL	199.0129 mL
5 mM	0.7961 mL	3.9803 mL	7.9605 mL	39.8026 mL
10 mM	0.3980 mL	1.9901 mL	3.9803 mL	19.9013 mL
20 mM	0.1990 mL	0.9951 mL	1.9901 mL	9.9506 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0796 mL	0.3980 mL	0.7961 mL	3.9803 mL
100 mM	0.0398 mL	0.1990 mL	0.3980 mL	1.9901 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

TNF-αMMPMatrix metalloproteinasesInhibitorinhibitCordycepinBacterialAutophagyAntibiotic

Related Tags: Cordycepin chemical structure | Cordycepin formula | Cordycepin molecular weight