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Citronellol [106-22-9]

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Référence NB-64-20779-2g

Conditionnement : 2g

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Citronellol

(Synonyms: dihydrogeraniol) Copy Product Info

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Synonyms: dihydrogeraniol

Catalog No. T3240 Copy Product Info

Purity: 99.56%

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Citronellol ((±)-β-Citronellol) is used in insect repellents and perfumes and as a mite attractant.

Cas No. 106-22-9

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.56%

Appearance:Liquid

Color:Transparent

Product Introduction

Citronellol AI Summary

Citronellol demonstrates a diverse range of biological activities and inhibitory effects against various targets. It has antiplasmodial activity with an IC50 of 192,000.0 nM against chloroquine-resistant Plasmodium falciparum FcM29-Cameroon but does not exhibit significant antifungal activity against Candida albicans ATCC 90028 (MIC > 200.0 ug/mL). The compound shows inhibition of COX2 by less than 30.0% at 100 uM and is identified as a potential inhibitor of Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 3548.1 nM. It also inhibits 15-human lipoxygenase (15-hLO) with a potency of 7943.3 nM and modulates lipid storage with a potency of 39810.7 nM. Additionally, it exhibits agonistic activity toward the antioxidant response element (ARE) signaling pathway with a potency of 74978.0 nM and is a potential inhibitor of human tyrosyl-DNA phosphodiesterase 1 (TDP1) with a potency of 32642.7 nM. Citronellol is characterized by specific activity against human recombinant UGT1A1, demonstrating 0.0 pm/min/mg activity. It shows strong repellent activity against Tribolium castaneum and insecticidal activity against Leptinotarsa decemlineata and two-spotted spider mites, including insecticidal efficacy against both susceptible and resistant strains. The compound exhibits fungitoxicity against Colletotrichum gloeosporioides (EC50 = 84.0 ug/mL and 537031.8 nM) and antimicrobial activity against Mycobacterium tuberculosis H37Rv, with complete growth inhibition at 64.0 ug/mL. Additionally, Citronellol exhibits mixed activities on transient receptor potential (TRP) channels, with varying levels of agonist and antagonist effects on TRPV1, TRPA1, and TRPM8. It also shows inhibitory activity against ARAT in bovine RPE microsomes (30% inhibition at 100 uM) and no inhibitory activity towards LRAT under similar conditions. The compound has a logP value of 3.91, indicating moderate lipophilicity, and displays varied bioactivities against multiple microbial and insect targets..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Citronellol ((±)-β-Citronellol) is used in insect repellents and perfumes and as a mite attractant.
Synonyms	dihydrogeraniol

Chemical Properties

Molecular Weight	156.27
Formula	C₁₀H₂₀O
Cas No.	106-22-9
Smiles	C(CCC=C(C)C)(CCO)C
Relative Density.	0.857 g/cm3 at 25℃ (lit.)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (319.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.8 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.3992 mL	31.9959 mL	63.9918 mL	319.9590 mL
5 mM	1.2798 mL	6.3992 mL	12.7984 mL	63.9918 mL
10 mM	0.6399 mL	3.1996 mL	6.3992 mL	31.9959 mL
20 mM	0.3200 mL	1.5998 mL	3.1996 mL	15.9980 mL
50 mM	0.1280 mL	0.6399 mL	1.2798 mL	6.3992 mL
100 mM	0.0640 mL	0.3200 mL	0.6399 mL	3.1996 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

β-CitronellolReactiveOxygenSpeciesReactive Oxygen SpeciesCitronellolbeta-Citronellolb-Citronellol(±)-Citronellol

Related Tags: Citronellol chemical structure | Citronellol formula | Citronellol molecular weight