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Cefotaxime [63527-52-6]

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Référence NB-64-42372-500mg

Conditionnement : 500mg

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Cefotaxime

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Synonyms:

Catalog No. T7733 Copy Product Info

Purity: 99.77%

Cefotaxime is an inhibitor of penicillin binding protein.

Cas No. 63527-52-6

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.77%

Color:Yellow

Product Introduction

Cefotaxime AI Summary

Cefotaxime exhibits broad-spectrum antibacterial activity against a variety of bacterial pathogens, including Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Streptococcus pyogenes, with notable low minimum inhibitory concentrations (MIC) indicative of its potent antibacterial efficacy. Specific MIC values include 0.06 ug/mL against Klebsiella pneumoniae and 0.03 ug/mL against Escherichia coli strains, highlighting its broad applicability. Additionally, the compound shows inhibitory effects on penicillin-binding proteins (PBPs) and various beta-lactamases, enhancing its effectiveness against resistant bacterial strains. In vivo murine models evidenced its therapeutic potential at effective doses (ED50) for infectious treatments. While demonstrating strong in vitro and in vivo results, Cefotaxime exhibits differential activity with reduced effectiveness against multi-resistant strains such as certain Pseudomonas aeruginosa and Staphylococcus aureus strains. Documented pharmacokinetic properties indicate a short half-life and high clearance rate, necessitating considerations in dosing regimens for clinical applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cefotaxime is an inhibitor of penicillin binding protein.

Chemical Properties

Molecular Weight	455.47
Formula	C₁₆H₁₇N₅O₇S₂
Cas No.	63527-52-6
Smiles	C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC)/C=3N=C(N)SC3)=O)C2=O)(SCC1COC(C)=O)09
Relative Density.	1.8 g/cm3

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 255 mg/mL (559.86 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.25 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1955 mL	10.9777 mL	21.9553 mL	109.7767 mL
5 mM	0.4391 mL	2.1955 mL	4.3911 mL	21.9553 mL
10 mM	0.2196 mL	1.0978 mL	2.1955 mL	10.9777 mL
20 mM	0.1098 mL	0.5489 mL	1.0978 mL	5.4888 mL
50 mM	0.0439 mL	0.2196 mL	0.4391 mL	2.1955 mL
100 mM	0.0220 mL	0.1098 mL	0.2196 mL	1.0978 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

InhibitorinhibitHR-756HR756HR 756CefotaximeCefotaximBacterialAnti-infectionAntiinfectionAntibiotic

Related Tags: Cefotaxime chemical structure | Cefotaxime formula | Cefotaxime molecular weight

Cefotaxime [63527-52-6]

Référence NB-64-42372-500mg

Contactez votre distributeur local :

Contactez votre distributeur local :

Cefotaxime

Product Introduction

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Keywords

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