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Butylated hydroxytoluene [128-37-0]

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Référence NB-64-01097-1mL

Conditionnement : 1mLx10mM(inDMSO)

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Butylated hydroxytoluene

(Synonyms: BHT FCC/NF) Copy Product Info

Synonyms: BHT FCC/NF

Catalog No. T0935 Copy Product Info

Purity: 99.72%

Butylated hydroxytoluene (BHT FCC/NF) is an antioxidant widely used in food, cosmetics and industrial liquids. It is a ferroptosis inhibitor.

Cas No. 128-37-0

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.72%

Appearance:Solid

Color:White

Product Introduction

Butylated hydroxytoluene AI Summary

Butylated hydroxytoluene displays significant antioxidant activity across a multitude of assays and concentrations. It demonstrates a notable ability to inhibit lipid peroxidation in various tissues, including rat brain and liver microsomes, with IC50 values ranging from 0.1 µg/mL to 59,000 nM. Its time-dependent antioxidative properties are evident in AAPH-induced MDA assays and other experimental setups, showing decreased activity over longer incubations. Additionally, Butylated hydroxytoluene exhibits a range of radical scavenging activities, including DPPH, ABTS, nitric oxide, hydroxyl, and superoxide radicals. It shows variable efficacy in different assays, with IC50 values for DPPH radical scavenging reported between 16.47 µg/mL and 90900 nM. It also inhibits lipid peroxidation induced by ferrous ions and AAPH in different models. Moreover, Butylated hydroxytoluene has shown neuroprotective and cytoprotective effects, demonstrated by its ability to protect cerebellar granule cells from iodoacetate-induced toxicity and to inhibit cellular death in C6 glial cells. It has been reported to enhance recovery from coma, evidenced by improved survival times and behavioral responses in mice. The compound also exhibits anti-hypoxic, anti-inflammatory, and enzyme regulatory activities. It inhibits human erythrocyte CA1 and CA2 esterase activity, as well as platelet aggregation induced by platelet-activating factors. Furthermore, Butylated hydroxytoluene has a potential use in reducing oxidative stress and protecting against cellular damage in ischemic conditions. Finally, the compound shows antibacterial and antibiofilm activities, against strains like Vibrio harveyi, and demonstrates synergistic effects when combined with other agents. Its ability to inhibit quorum sensing, reduce biofilm formation, and enhance cell viability in infected organisms highlights its potential therapeutic applications in infectious diseases..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Butylated hydroxytoluene (BHT FCC/NF) is an antioxidant widely used in food, cosmetics and industrial liquids. It is a ferroptosis inhibitor.
Synonyms	BHT FCC/NF

Chemical Properties

Molecular Weight	220.35
Formula	C₁₅H₂₄O
Cas No.	128-37-0
Smiles	OC=1C(=CC(=CC1C(C)(C)C)C)C(C)(C)C
Relative Density.	1.048 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 242.5 mg/mL (1100.52 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5382 mL	22.6912 mL	45.3823 mL	226.9117 mL
5 mM	0.9076 mL	4.5382 mL	9.0765 mL	45.3823 mL
10 mM	0.4538 mL	2.2691 mL	4.5382 mL	22.6912 mL
20 mM	0.2269 mL	1.1346 mL	2.2691 mL	11.3456 mL
50 mM	0.0908 mL	0.4538 mL	0.9076 mL	4.5382 mL
100 mM	0.0454 mL	0.2269 mL	0.4538 mL	2.2691 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

InhibitorinhibitFerroptosisButylated hydroxytolueneAntioxidant

Related Tags: Butylated hydroxytoluene chemical structure | Butylated hydroxytoluene formula | Butylated hydroxytoluene molecular weight

Butylated hydroxytoluene [128-37-0]

Référence NB-64-01097-1mL

Contactez votre distributeur local :

Contactez votre distributeur local :

Butylated hydroxytoluene

Product Introduction

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Keywords

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