Anti-14-3-3 sigma Antibody (2I538)
Référence NB-64-115357-100uL
Conditionnement : 100uL
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Anti-14-3-3 sigma Antibody (2I538)
(Synonyms: YWHAS, stratifin, 14-3-3 σ) Copy Product InfoSynonyms: YWHAS, stratifin, 14-3-3 σ
Catalog No. TMAC-00007 Copy Product Info
Anti-14-3-3 sigma Antibody (2I538) is a Rabbit antibody targeting 14-3-3 sigma. Anti-14-3-3 sigma Antibody (2I538) can be used in IHC,WB.
For research use only—not for human use. No sales to individuals. Use as intended only.
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
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| Description | Anti-14-3-3 sigma Antibody (2I538) is a Rabbit antibody targeting 14-3-3 sigma. Anti-14-3-3 sigma Antibody (2I538) can be used in IHC,WB. |
| Synonyms | YWHAS, stratifin, 14-3-3 σ |
| Ig Type | IgG |
| Clone | 2I538 |
| Reactivity | Human,Rat |
| Verified Activity | 1. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-14-3-3 sigma antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-14-3-3 sigma antibody. Counter stained with hematoxylin.  , |
| Application | IHC WB |
| Recommended Dose | WB: 1:1000; IHC: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | 14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms, denoted 14-3-3 b, g, e, z, h, q and s, comprise this family of signaling intermediates. 14-3-3 s, also known as SFN, stratifin, HME1 or YWHAS, is a secreted adaptor protein that is involved in regulating both general and specific signaling pathways. Expressed predominately in stratified squamous keratinising epithelium, 14-3-3 s is able to bind and modify the activity of a large number of proteins, such as KRT17 (Keratin 17), through recognition of a phosphothreonine or phosphoserine motif. When bound to Keratin 17, for example, 14-3-3 s acts to stimulate the Akt/mTOR signaling pathway by upregulating protein synthesis and cell growth. 14-3-3 s also functions to positively mediate IGF-I-induced cell cycle progression and can bind to a variety of translation initiation factors, thus controlling mitotic translation. In response to tumor growth, 14-3-3 s positively regulates the tumor suppressor p53 and increases the rate of p53-regulated inhibition of G2/M cell cycle progression. Multiple isoforms of 14-3-3 s exist due to alternative splicing events. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID | P31947 |
| Molecular Weight | Theoretical: 28 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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