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> NFKB1 Protein, Human, Recombinant (His)

NFKB1 Protein, Human, Recombinant (His)

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NFKB1 Protein, Human, Recombinant (His)

(Synonyms: Nuclear factor of κ light polypeptide gene enhancer in B-cells 1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, EBP-1, DNA-binding factor KBF1) Copy Product Info

Synonyms: Nuclear factor of κ light polypeptide gene enhancer in B-cells 1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, EBP-1, DNA-binding factor KBF1

Catalog No. TMPJ-00887 Copy Product Info
The 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
Other Forms of NFKB1 Protein, Human, Recombinant (His):
EBP1 Protein, Human, Recombinant (His)TMPY-02844
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:Greater than 90% as determined by reducing SDS-PAGE.
Appearance:Lyophilized powder
Color:White
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Product Information

Bioactivity
Bioactivity
Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description
The 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
Species
Human
Expression System
E. coli
TagN-6xHis
Accession NumberP19838-2
Amino AcidMet1-Gly434
ConstructionMet1-Gly434
Protein Purity
Greater than 90% as determined by reducing SDS-PAGE. (QC verified)
Endotoxin< 0.1 ng/µg (1 EU/µg) as determined by LAL test.
FormulationLyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM Tris-HCl, 150 mM NaCl, 20 mM GSH, pH 8.0.
ReconstitutionReconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
SynonymsNuclear factor of κ light polypeptide gene enhancer in B-cells 1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, EBP-1, DNA-binding factor KBF1
Research Background
The 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene.
Chemical Properties
Molecular Weight45-55 KDa (reducing condition)
Storage & Solubility Information
ShippingIn general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
StorageIt is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

EBP1EBP 1
Related Tags: NFKB1 Protein, Human, Recombinant (His) chemical structure | NFKB1 Protein, Human, Recombinant (His) molecular weight