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trans-Zeatin [1637-39-4]

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Referencia NB-64-61777-10mg

embalaje : 10mg

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trans-Zeatin

(Synonyms: (E)-Zeatin) Copy Product Info

Synonyms: (E)-Zeatin

Catalog No. TMS2181 Copy Product Info

Purity: 98.96%

trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing.

Cas No. 1637-39-4

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.96%

Color:White

Product Introduction

trans-Zeatin AI Summary

trans-Zeatin exhibits diverse bioactivities across several biological systems and assays. In plants, it demonstrates cytokinin-like effects, activating AHK3 and AHK4/CRE1 receptors in Arabidopsis thaliana to stimulate beta-galactosidase activity, promoting callus growth in tobacco, betacyanin synthesis in Amaranthus cotyledons, and chlorophyll retention in wheat, comparable to 6-benzylaminopurine. It inhibits RECQ1 DNA helicase with a potency of 2818.4 nM and APE1 with a potency of 1122.0 nM. It acts as an agonist of the Thyroid Stimulating Hormone Receptor, affecting intracelular cAMP concentrations in Parental HEK 293 cells (19952.6 nM). Additionally, it inhibits PTHR (11220.2 nM) and shows effects on Anthrax Lethal Toxin Internalization (12589.3 nM). trans-Zeatin has antiviral properties, inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 and VERO-6 cells at 10 µM concentration with varying inhibition levels, and shows SARS-CoV-2 3CL-Pro protease inhibition with activity percentages up to 19.53% at 20 µM. The compound also exhibits inhibitory activity against human HDAC6 enzyme with low percentages of inhibition in enzymatic assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing.
Synonyms	(E)-Zeatin

Chemical Properties

Molecular Weight	219.24
Formula	C₁₀H₁₃N₅O
Cas No.	1637-39-4
Smiles	CC(CO)=CCNc1ncnc2[nH]cnc12
Relative Density.	1.40 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 35.71 mg/mL (162.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 4.95 mg/mL (22.58 mM), Solution.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (4.56 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.5612 mL	22.8061 mL	45.6121 mL	228.0606 mL
5 mM	0.9122 mL	4.5612 mL	9.1224 mL	45.6121 mL
10 mM	0.4561 mL	2.2806 mL	4.5612 mL	22.8061 mL
20 mM	0.2281 mL	1.1403 mL	2.2806 mL	11.4030 mL
50 mM	0.0912 mL	0.4561 mL	0.9122 mL	4.5612 mL
100 mM	0.0456 mL	0.2281 mL	0.4561 mL	2.2806 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

Zeatintrans-ZeatintransZeatintrans ZeatinMitogen-activated protein kinase kinaseMEKMAPKKMAP2KInhibitorinhibitExtracellular signal regulated kinasesERKEndogenousMetaboliteEndogenous Metabolite

Related Tags: trans-Zeatin chemical structure | trans-Zeatin formula | trans-Zeatin molecular weight

trans-Zeatin [1637-39-4]

Referencia NB-64-61777-10mg

Contact local distributor :

Contact local distributor :

trans-Zeatin

Product Introduction

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Keywords

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