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Isolongifolene [1135-66-6]

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Referencia NB-64-02995-25mg

embalaje : 25mg

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Isolongifolene

(Synonyms: (-)-Isolongifolene) Copy Product Info

Synonyms: (-)-Isolongifolene

Catalog No. T11685 Copy Product Info

Purity: 99.46%

Isolongifolene ((-)-Isolongifolene), a tricyclic sesquiterpene isolated from Murraya koenigii, exhibits antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. It mitigates Rotenone-induced oxidative stress, mitochondrial dysfunction, and apoptosis by modulating the PI3K/AKT/GSK-3β signaling pathways.

Cas No. 1135-66-6

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.46%

Product Introduction

Bioactivity

Description	Isolongifolene ((-)-Isolongifolene), a tricyclic sesquiterpene isolated from Murraya koenigii, exhibits antioxidant, anti-inflammatory, anticancer, and neuroprotective properties. It mitigates Rotenone-induced oxidative stress, mitochondrial dysfunction, and apoptosis by modulating the PI3K/AKT/GSK-3β signaling pathways.
In vitro	isolongifolene (ILF), a tricyclic sesquiterpene of Murraya koenigii, against rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis in a cellular model.
Synonyms	(-)-Isolongifolene

Chemical Properties

Molecular Weight	204.35
Formula	C₁₅H₂₄
Cas No.	1135-66-6
Smiles	13[C@]12CC[C@]3(C1)C(=CCCC3(C)C)C2(C)C
Relative Density.	0.930 g/cm3 at 20℃ (lit.)

Storage & Solubility Information

Storage

Store under nitrogen,Store at low temperature Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (122.34 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 1 mg/mL (4.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.8936 mL	24.4678 mL	48.9356 mL	244.6782 mL
5 mM	0.9787 mL	4.8936 mL	9.7871 mL	48.9356 mL
10 mM	0.4894 mL	2.4468 mL	4.8936 mL	24.4678 mL
20 mM	0.2447 mL	1.2234 mL	2.4468 mL	12.2339 mL
50 mM	0.0979 mL	0.4894 mL	0.9787 mL	4.8936 mL
100 mM	0.0489 mL	0.2447 mL	0.4894 mL	2.4468 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

TricyclicsesquiterpeneRotenoneROSmitochondrialIsolongifoleneInhibitorinhibitdysfunctioncytotoxicityApoptosisantioxidantanti-inflammatoryanticancer

Related Tags: Isolongifolene chemical structure | Isolongifolene in vitro | Isolongifolene formula | Isolongifolene molecular weight