embalaje : 25mg
Teléfono : +1 850 650 7790
Synonyms:
| Description | Isochenodeoxycholic Acid-D4 is a deuterated derivative of Isochenodeoxycholic Acid (T207107), which can be used for isotope-labeled isomeric bile acid metabolism and signaling research. Isochenodeoxycholic Acid can activate farnesoid X receptor (FXR) signaling in cell systems and induce FXR target genes Ostβ and Kng1 in HepG2 cells. Isochenodeoxycholic Acid can also serve as a substrate for recombinant human class I alcohol dehydrogenase γγ-mediated 3β-dehydrogenation, with a catalytic efficiency of 0.09 min−1·μmol/L−1. Isochenodeoxycholic Acid-D4 can support analytical tracer research on bile acid metabolism, FXR-related signaling, and isochenodeoxycholic acid conversion processes. |
| Molecular Weight | 396.6 |
| Formula | C24H36D4O4 |
| Smiles | OC(CC[C@H]([C@@]1(05)CC[C@@]2(05)[C@]3(05)[C@H](O)C[C@]4(05)C([2H])([2H])[C@@H](O)C([2H])([2H])C[C@]4(C)[C@@]3(05)CC[C@]12C)C)=O |
| Storage | Store under nitrogen,Store at low temperature,Keep away from moisture,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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