Bobcat339 [2280037-51-4]
Katalog-Nummer NB-64-29629-5mg
Size : 5mg
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Bobcat339
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Catalog No. T5198 Copy Product Info
Purity: 99.67%
Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
Cas No. 2280037-51-4
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.67%
Appearance:Solid
Color:White to Cyan
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Product Information
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a. |
| Targets & IC50 | TET1:33 μM (cell free), TET2:73 μM (cell free) |
| In vitro | HT-22 cells were treated with 10 μM Bobcat339 in 1% DMSO for 24 hrs and lysed. Cells treated with Bobcat339 had significantly reduced global 5hmC levels as compared to vehicle control. |
| Molecular Weight | 297.74 |
| Formula | C16H12ClN3O |
| Cas No. | 2280037-51-4 |
| Smiles | Nc1nc(=O)n(cc1Cl)-c1cccc(c1)-c1ccccc1 |
| Relative Density. | 1.33 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 11.59 mg/mL (38.93 mM), Sonication is recommended.  | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.72 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||