Wilms Tumor Protein protein

Formulation:	Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	WT1
Gene ID:	7490
Uniprot ID:	WT1_HUMAN
Specificity:	This is positive control is recommended for use in combination with Wilms Tumor Protein antibody STJ505992.
Immunogen:	Wilms tumor protein WT1

Tissue Specificity	Expressed in the kidney and a subset of hematopoietic cells.
Function	Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
Peptide Name	Wilms Tumor Protein Wt33
Database Links	Reactome: R-HSA-9690406
Cellular Localisation	Nucleus Nucleolus Cytoplasm Isoforms Lacking The Kts Motif Have A Diffuse Nuclear Location Shuttles Between Nucleus And Cytoplasm Isoform 1: Nucleus Speckle Isoform 4: Nucleus Nucleoplasm
Alternative Peptide Names	Wilms Tumor Protein protein Wt33 protein WT1 protein

Information sourced from Uniprot.org

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