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Sodium dodecyl sulfate [151-21-3]

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Katalog-Nummer NB-64-09868-1mL

Size : 1mLx10mM(inDMSO)

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Sodium dodecyl sulfate

(Synonyms: Sodium lauryl sulfate, Sodium dodecylsulfate, SDS, NSC-402488, NSC402488, NSC 402488, Natrium laurylsulfuricum, Laurylsulfuric acid sodium salt, Anticerumen) Copy Product Info

Synonyms: Sodium lauryl sulfate, Sodium dodecylsulfate, SDS, NSC-402488, NSC402488, NSC 402488, Natrium laurylsulfuricum, Laurylsulfuric acid sodium salt, Anticerumen

Catalog No. T20075 Copy Product Info

Purity: 99.75%

Sodium dodecyl sulfate(Sodium lauryl sulfate) is a pharmaceutical excipient that is biologically inactive and improves the stability, solubility and processability of pharmaceutical preparations.

Cas No. 151-21-3

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.75%

Appearance:Solid

Color:White

Product Introduction

Sodium dodecyl sulfate AI Summary

Sodium dodecyl sulfate exhibits a diverse range of biological activities. It demonstrates a dose-dependent hemolytic effect on rat red blood cells, with hemolysis increasing from 12.25% at 1 mM concentration to 62.66% at 5 mM. In antimicrobial studies, it shows significant activity against various strains of Escherichia coli, including multidrug-resistant strains, with Minimum Inhibitory Concentration (MIC) values ranging from 62.5 µg/mL to 128.0 µg/mL. It also exhibits antibacterial activity against Enterobacter cloacae, Enterococcus faecalis, Proteus mirabilis, and methicillin-resistant Staphylococcus aureus, and antifungal activity against Candida species. Additionally, it has potent anti-inflammatory properties by inhibiting IL1alpha release in a reconstituted human epidermis model. In terms of cytotoxicity, Sodium dodecyl sulfate is highly potent against human HepG2/C3A cells with an IC50 value of 0.222 nM, and it shows lesser toxicity against mouse RAW264.7 and human HCT116 cells, with IC50 values greater than 100,000 nM. The compound also presents impacting activities against Steinernema feltiae in nematicidal assays and induces membrane permeabilization. Biosurfactant properties are indicated by its ability to lower surface tension, with a critical micelle concentration (CMC) of 8.2 mM and activity in oil displacement assays. Furthermore, it displays significant inhibition of full-length human soluble epoxide hydrolase phosphatase activity, stabilizing the phosphatase domain while showing weaker activity against the hydrolase domain. Sodium dodecyl sulfate's broad spectrum of activities position it as a potential candidate for therapeutic applications involving antimicrobial, anti-inflammatory, and cytotoxic properties..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sodium dodecyl sulfate(Sodium lauryl sulfate) is a pharmaceutical excipient that is biologically inactive and improves the stability, solubility and processability of pharmaceutical preparations.
Synonyms	Sodium lauryl sulfate, Sodium dodecylsulfate, SDS, NSC-402488, NSC402488, NSC 402488, Natrium laurylsulfuricum, Laurylsulfuric acid sodium salt, Anticerumen

Chemical Properties

Molecular Weight	288.38
Formula	C₁₂H₂₅NaO₄S
Cas No.	151-21-3
Smiles	O=S([O-])(OCCCCCCCCCCCC)=O.[Na+]
Relative Density.	1.03 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (208.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4676 mL	17.3382 mL	34.6765 mL	173.3823 mL
5 mM	0.6935 mL	3.4676 mL	6.9353 mL	34.6765 mL
10 mM	0.3468 mL	1.7338 mL	3.4676 mL	17.3382 mL
20 mM	0.1734 mL	0.8669 mL	1.7338 mL	8.6691 mL
50 mM	0.0694 mL	0.3468 mL	0.6935 mL	3.4676 mL
100 mM	0.0347 mL	0.1734 mL	0.3468 mL	1.7338 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

Keywords

Sodium lauryl Sulfate

Related Tags: Sodium dodecyl sulfate chemical structure | Sodium dodecyl sulfate formula | Sodium dodecyl sulfate molecular weight