Resveratrol [501-36-0]

Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.

Adenylyl cyclase:0.8 nM, IKKβ:1 μM, DNA polymerase δ:5 μM (cell free), DNA polymerase α:3.3 μM (cell free), DNA polymerase δ:5 μM (cell free), DNA polymerase α:3.3 μM (cell free), COX-1:1.1 μM (cell free), COX-2:1.3 μM (cell free)

METHODS: Mouse mammary carcinoma cells 4T1 were treated with Resveratrol (50-250 μM) for 72 h. Cell viability was measured by CCK-8.
RESULTS: Resveratrol dose-dependently inhibited the viability of 4T1 cells with an IC50 of 93 μM. [1]
METHODS: Human breast cancer cells MCF-7 were treated with Resveratrol (1-100 μM) for 24 h, and the intracellular ATP content was detected by luciferin-luciferase assay.
RESULTS: Resveratrol decreased the cellular ATP content. It was reduced by about 16% at 1 μM Resveratrol and 50% at 100 μM Resveratrol. [2]

METHODS: To assay anti-tumor activity in vivo, Resveratrol (50-100 mg/kg, 5% ethanol and 25% polyethyleneglycol 400 in distilled water) was intraperitoneally injected into BALB/c (nu/nu) mice harboring the human ovarian teratoma PA-1 once daily for four weeks.
RESULTS: Resveratrol inhibited the growth of PA-1 cell xenografts and eEF1A2 expression. [3]
METHODS: To study the effects on depressed mice, Resveratrol (10-30 mg/kg) was administered intraperitoneally once daily for 21 days to C57BL/6 mice, a model of depression.
RESULTS: Resveratrol significantly increased the levels of the prefrontal cortex neurotransmitters DA and 5-HT, and increased the expression of NPY in the brain, which antagonized depression. [4]

HAECs were treated with RSV in the presence of isobutylmethylxanthine (IBMX). The reaction was sto