Polymyxin B [1404-26-8]
Katalog-Nummer NB-64-43126-50mg
Size : 50mg
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Polymyxin B
Polymyxin B is a polymyxin antibiotic with antimicrobial activity that acts by binding with high affinity to the LPS of the bacterial wall and by increasing the permeability of the bacterial cell membrane, and is used in the study of infections caused by drug-resistant (XDR) Gram-negative bacteria (GNB) Polymyxin B is used in the study of endotoxemia.
Polymyxin B
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Polymyxin B is a polymyxin antibiotic with antimicrobial activity that acts by binding with high affinity to the LPS of the bacterial wall and by increasing the permeability of the bacterial cell membrane, and is used in the study of infections caused by drug-resistant (XDR) Gram-negative bacteria (GNB) Polymyxin B is used in the study of endotoxemia. |
| In vitro | 10 μg/mL Polymyxin B, treated for 6 hours, reduced TNF-α and IL-10 production in human peripheral blood mononuclear cells (PBMCs). [3] |
| In vivo | Polymyxin B was administered intravenously once daily for seven consecutive days at a dose range of 5-20 mg/kg Polymyxin B. The treatment of PBMCs with Polymyxin B for six hours reduced TNF-α and IL-10 production. A nephrotoxicity endpoint was observed in the Sprague-Dawley rat model at the 20 mg/kg dose, whereas no such endpoint was observed at the 5 mg/kg dose. [2] |
| Cas No. | 1404-26-8 |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O: 16.67 mg/mL, Sonication is recommended.  |