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N-Acetylneuraminic acid [131-48-6]

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Katalog-Nummer NB-64-07440-1mL

Size : 1mLx10mM(inDMSO)

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Telefonnummer : +1 850 650 7790

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N-Acetylneuraminic acid

(Synonyms: NeuAc, Lactaminic acid, Acide aceneuramique) Copy Product Info

Synonyms: NeuAc, Lactaminic acid, Acide aceneuramique

Catalog No. T1638 Copy Product Info

Purity: 99.97%

N-Acetylneuraminic acid (Acide aceneuramique) is a nine-carbon sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells. Studies have shown that N-Acetylneuraminic acid is biologically useful for neurotransmission, leukocyte extravasation, viral or bacterial infections, and carbohydrate-protein recognition.

Cas No. 131-48-6

For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.97%

Appearance:Solid

Color:White

Product Introduction

N-Acetylneuraminic acid AI Summary

N-Acetylneuraminic acid exhibits a range of inhibitory and bioactive properties. It has been tested for inhibition of Influenza sialidase type A and type B, with an IC50 of 1000000.0 nM in both assays, indicating potential but low-level inhibitory effects. The compound is effective in several bioassays: - It counters cytotoxicity in the Nrf2 qHTS screen with a potency of 651.3 nM. - It inhibits Importin-beta complex formation in the Rango assay with a potency of 125892.5 nM. - It inhibits HP1-beta Chromodomain interactions with methylated histone tails with a potency of 89125.1 nM. - It demonstrates inhibitory activity against Hepatitis C Virus (HCV) with a potency of 3162.3 nM. - It exhibits antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in Caco-2 cells (16.52% inhibition at 10 µM after 48 hours) and against the SARS-CoV-2 3CL-Pro protease (41.21% at 20 µM). However, the compound shows lower efficacy in inhibiting SARS-CoV-2 cytotoxicity in VERO-6 cells, with IC50 values above 50100.0 nM. Additionally, N-Acetylneuraminic acid moderately inhibits human HDAC6 (-21.56% using a commercial peptide substrate) but shows no significant inhibition against human NEU1, NEU2, NEU3, and NEU4, with IC50 values greater than 500000.0 nM. The compound also has a dissociation constant (pKa) of 3.2. Further studies are necessary to fully understand its bioactivity and therapeutic potential..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	N-Acetylneuraminic acid (Acide aceneuramique) is a nine-carbon sialic acid monosaccharide commonly found in glycoproteins on cell membranes and in glycolipids such as gangliosides in mammalian cells. Studies have shown that N-Acetylneuraminic acid is biologically useful for neurotransmission, leukocyte extravasation, viral or bacterial infections, and carbohydrate-protein recognition.
Synonyms	NeuAc, Lactaminic acid, Acide aceneuramique

Chemical Properties

Molecular Weight	309.27
Formula	C₁₁H₁₉NO₉
Cas No.	131-48-6
Smiles	[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)([C@H](CC(C(O)=O)=O)O)NC(C)=O
Relative Density.	1.3580 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 125 mg/mL (404.18 mM), Sonication is recommended.

DMSO: 122 mg/mL (394.48 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.2334 mL	16.1671 mL	32.3342 mL	161.6710 mL
5 mM	0.6467 mL	3.2334 mL	6.4668 mL	32.3342 mL
10 mM	0.3233 mL	1.6167 mL	3.2334 mL	16.1671 mL
20 mM	0.1617 mL	0.8084 mL	1.6167 mL	8.0836 mL
50 mM	0.0647 mL	0.3233 mL	0.6467 mL	3.2334 mL
100 mM	0.0323 mL	0.1617 mL	0.3233 mL	1.6167 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Keywords

NANAN-Acetylneuraminic acidNAcetylneuraminic acidN Acetylneuraminic acidInhibitorinhibitInfluenzaVirusInfluenza VirusEndogenousMetaboliteEndogenous Metabolite

Related Tags: N-Acetylneuraminic acid chemical structure | N-Acetylneuraminic acid formula | N-Acetylneuraminic acid molecular weight

N-Acetylneuraminic acid [131-48-6]

Katalog-Nummer NB-64-07440-1mL

Contact local distributor :

Contact local distributor :

N-Acetylneuraminic acid

Product Introduction

Calculator

In Vivo Formulation Calculator (Clear solution)

Dose Conversion

Keywords

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