Size : 10mL
Telefonnummer : +1 850 650 7790
Synonyms: Dipentene, (±)-α-Limonene, (±)-Limonene
| Description | Limonene (Dipentene) is a monoterpene found in citrus plants such as lemon, orange, and grape, widely used in cosmetics and household products as a fragrance, with antimicrobial, antiproliferative, antioxidant, and anti-inflammatory properties. |
| In vitro | Limonene exerts anti-inflammatory effects by reducing pro-inflammatory cytokines (TNF-α, IL-1β, COX-2), inhibiting TLR4/NF-κB/AP-1 but not the IRF3 signaling pathway, and regulating oxidative stress through Nrf2 activation. [1] Limonene treatment inhibits UVB-induced α-MSH secretion and then suppresses melanocortin (POMC) by inhibiting p53 transcriptional activation. [2] |
| In vivo | Limonene (100 and 200 mg/kg, orally administered) in LPS mouse models mitigated the decline in renal function due to LPS induction, resulting in reduced serum urea and creatinine levels in mice. [1] Limonene (20 mg/kg, intrabitoneally administered) reduced serum and brain nitrite levels and decreased the expression of IL-1β and TNF-α in the hippocampus of MS-stressed mice. [3] |
| Synonyms | Dipentene, (±)-α-Limonene, (±)-Limonene |
| Molecular Weight | 136.23 |
| Formula | C10H16 |
| Cas No. | 138-86-3 |
| Smiles | C=C(C)C1CC=C(C)CC1 |
| Relative Density. | 0.86 g/mL at 20 °C (lit.) |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 80 mg/mL (587.24 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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