IL-1 beta/IL-1F2 Protein, Human, Recombinant
Katalog-Nummer NB-64-56219-100ug
Size : 100ug
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IL-1 beta/IL-1F2 Protein, Human, Recombinant
(Synonyms: interleukin 1, β, interleukin 1, beta, IL1-β, IL1F2, IL1-BETA, IL-1B, IL-1 β, IL-1 beta, IL-1) Copy Product InfoSynonyms: interleukin 1, β, interleukin 1, beta, IL1-β, IL1F2, IL1-BETA, IL-1B, IL-1 β, IL-1 beta, IL-1
Catalog No. TMPY-01049 Copy Product Info
IL-1 beta/IL-1F2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17 kDa and the accession number is P01584.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:SDS-PAGE: 98.3%; SEC-HPLC: 99.7%
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 0.2-2 ng/mL. |
| Description | IL-1 beta/IL-1F2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17 kDa and the accession number is P01584. |
| Species | Human |
| Expression System | E. coli |
| Tag | Tag Free |
| Accession Number | P01584 |
| Construction | A DNA sequence encoding the mature form of human IL1β (NP_000567.1) (Ala 117-Ser 269) was expressed. Predicted N terminal: Met |
| Protein Purity | ≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.  , |
| Endotoxin | < 5 EU/mg of the protein as determined by the LAL method. |
| Formulation | Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization. |
| Reconstitution | Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot. |
| Synonyms | interleukin 1, β, interleukin 1, beta, IL1-β, IL1F2, IL1-BETA, IL-1B, IL-1 β, IL-1 beta, IL-1 |
| Research Background | Interleukin-1 beta (IL1 beta or IL1B) also known as catabolin, is a member of the interleukin 1 cytokine family. IL1 is a pleiotropic cytokine. It is involved in the inflammatory response, cell growth, and tissue repair in the cortex. The IL1 superfamily consists of three members, IL1A (IL1 alpha), IL1B (IL1 beta), and IL1 receptor antagonist (IL1Ra). In clinical, it has been reported that Interleukin (IL)-1 may influence Th1 / Th2 immune responsiveness and has been implicated in the establishment of a successful pregnancy. Proinflammatory interleukin (IL)-1 gene polymorphisms associated with high levels of IL-1beta activity increase the risk for hypochlorhydria and distal gastric carcinoma. IL1B polymorphisms may be involved in susceptibility to SSc. Moreover, the IL2-384-G allele may be a marker for the limited phenotype of systemic sclerosis (SSc).Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| Molecular Weight | 17 kDa (predicted); 17 kDa (reducing conditions) |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Storage | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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IL1IL 1
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Related Tags: IL-1 beta/IL-1F2 Protein, Human, Recombinant chemical structure | IL-1 beta/IL-1F2 Protein, Human, Recombinant molecular weight
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