Anti-GDNF Antibody (7K481)
Katalog-Nummer NB-64-116988-50uL
Size : 50uL
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Anti-GDNF Antibody (7K481)
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Catalog No. TMAC-01639 Copy Product Info
Anti-GDNF Antibody (7K481) is a Rabbit antibody targeting GDNF. Anti-GDNF Antibody (7K481) can be used in FCM,WB.
For research use only—not for human use. No sales to individuals. Use as intended only.
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-GDNF Antibody (7K481) is a Rabbit antibody targeting GDNF. Anti-GDNF Antibody (7K481) can be used in FCM,WB. |
| Ig Type | IgG |
| Clone | 7K481 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of GDNF on HepG2 cell using anti-GDNF antibody at 1/1,000 dilution. 2. Flow cytometric analysis of SH-SY5Y cells with GDNF antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black).  , |
| Application | FCM WB |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50-200; ICC: 1:50-200; FCM: 1:50-200 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | Glial cell line-derived neurotrophic factor (GDNF) has been identified as a potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons. GDNF is a glycosylated, disulfide-bonded homodimer and is a distantly related member of the TGFβ superfamily of growth regulatory ligands. GDNF contains the seven conserved cysteine residues in the same relative spacing characteristic of all members of the TGFβ superfamily. In embryonic midbrain cultures, GDNF promotes the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. On the basis of these findings, it has been suggested that GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID | P39905 |
| Molecular Weight | Theoretical: 24 kDa. |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Keywords
hGDNFGlial cell line-derived neurotrophic factorGDNFATFAstrocyte-derived trophic factor (ATF)
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