Size : 25mg
Telefonnummer : +1 850 650 7790
Synonyms: Alpha-caryophyllene
| Description | α-Humulene (Alpha-caryophyllene) is extracted from S.officinalis essential oil.α-Humulene can inhibit tumor cell growth.α-Humulene also shows anti-inflammatory effects, probably by interfering with TNFalpha production and COX-2 and iNOS expression. |
| In vitro | S. officinalis essential oil was obtained by hydrodistillation and fractionated with column chromatography; the essential oil and its fractions were analyzed by gas chromatography (GC) coupled to mass spectrometry (MS). The cytotoxic activity was evaluated in cellular lines of breast cancer MCF-7, colon cancer HCT-116, and murine macrophage RAW264.7 cell lines by the MTT assay Results: the sub-subfraction F1.1.1 of S. officinalis essential oil containing alpha-humulene present highest activity on RAW264.7 and HCT-116 with IC(50) values of 41.9 and 77.3 mu g/ml, respectively. The sub-subfraction F1.2.1 of S. officinalis essential oil with trans-caryophyllene(Alpha-caryophyllene) showed less activity on RAW246.7 and HCT-116 with IC(50) values of 90.5 and 145.8 mu g/ml. |
| Synonyms | Alpha-caryophyllene |
| Molecular Weight | 204.35 |
| Formula | C15H24 |
| Cas No. | 6753-98-6 |
| Smiles | C\C1=C/CC(C)(C)\C=C\C\C(C)=C\CC1 |
| Relative Density. | 1.31g/cm3 |
| Storage | Store at low temperature,Keep away from moisture,Keep away from direct sunlight Pure form: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ether: Soluble DMSO: 50 mg/mL (244.68 mM), Sonication is recommended.  Ethanol: Soluble | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 2.5 mg/mL (12.23 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
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