DNA methyltransferase (DNMT) antibodies are essential research tools for detecting DNMT1, DNMT3A, and DNMT3B, the enzymes responsible for maintaining and establishing DNA methylation patterns. They are widely used to investigate epigenetic regulation, gene silencing, development, and diseases such as cancer.
Specifications
DNMT antibodies are available as rabbit monoclonal or polyclonal antibodies, with mouse-derived formats also offered. Product specifications generally include the target isoform, clonality, species reactivity, epitope, conjugation status, and validation data.
- Targets: DNMT1, DNMT3A, and DNMT3B.
- Applications: Western blot, immunofluorescence, immunohistochemistry, ChIP, immunoprecipitation, and ELISA.
- Validation: Frequently knockout validated with publication support.
Research Applications
DNMT antibodies are used to measure protein expression, determine nuclear localization, investigate chromatin interactions, and analyze epigenetic mechanisms. They are particularly valuable in cancer research, where abnormal DNMT expression contributes to altered DNA methylation and inappropriate gene silencing.
